FluoroFinder

	Supplier	BioLegend
	Catalog #:	144805 (View supplier product page)
	Size	25 μg
	Price	$159.00
	Antigen	CD124
	Clone	I015F8
	Host	Rat
	Isotype	IgG2b κ
	Conjugate	PE-Cy7
	Target Species	Mouse
	Applications	FC
	Description	PE/Cyanine7 anti-mouse CD124 (IL-4Ralpha)

	CD124	This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
	PE-Cy7	PE-Cyanine®7 (PE-Cy7, RPE-Cy7) is a far red-emitting tandem fluorophore that combines phycoerythrin (PE) and Cy7. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Cy7, which emits light that can be captured with a 780/60 nm bandpass filter. PE-CY7 has an excitation peak at 565 nm and an emission peak at 778 nm, and is a suitable alternative to PE-Vio®770 (Miltenyi) and cFluor BYG781 (Cytek).

		C57BL/6 mouse splenocytes were stained with B220 Alexa Fluor 488® and CD124 (clone I015F8) PE/Cy7 (top image) or rat IgG2b, κ PE/Cy7 (bottom image).