LC3 / Biotin / Polyclonal

Product Details
Supplier Thermo Fisher Scientific
Catalog #: PA522709 (View supplier product page)
Size 100 μl
Price $354.00
Antigen LC3
Clone Polyclonal
Host Rabbit
Isotype IgG
Conjugate Biotin
Target Species Bacteria, Hamster, Human, Mouse, Porcine, Rat, Zebrafish
Applications IP, WB
Description LC3 Polyclonal Antibody, Biotin conjugate. LC3, a mammalian homologue of Apg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is the first mammalian protein identified that specifically associates with the autophagosome membranes.IHC (P) 1:200-1:400, IP 20 µg/500 µg of protein, WB 2 µg/ml
About LC3 and Biotin
LC3 MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
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Biotin Excitation and Emission Spectra