BCR / Janelia Fluor 646 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-19097JF646 (View supplier product page)
Size 100 μl
Price $559.00
Antigen BCR
Clone
Host Rabbit
Isotype IgG
Conjugate Janelia Fluor 646
Target Species Human
Applications FC, IP
Description BCR Antibody [Janelia Fluor® 646]
About BCR and Janelia Fluor 646
BCR A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Janelia Fluor 646 Excitation and Emission Spectra