Cdk6 / Biotin / DCS-83

Product Details
Supplier Thermo Fisher Scientific
Catalog #: MA513330 (View supplier product page)
Size 500 μl
Price $385.00
Antigen Cdk6
Clone DCS-83
Host Mouse
Isotype IgG1
Conjugate Biotin
Target Species Human, Mouse, Rat
Applications WB, IHC
Description Cdk6 Monoclonal Antibody, Biotin conjugate (K6.83 (DCS-83)). Cyclin-dependent kinase 6 (p40cdk6 also known as PLSTIRE) belongs to a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression.WB 1-2 µg/ml, IHC (P) 1:10-1:100, ICC 1:10-1:100, IF 1:10-1:100, IHC (F) Assay Dependent, IP 2 µg/ml
About Cdk6 and Biotin
Cdk6 The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
Citations
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Reviews & Ratings
Biotin Excitation and Emission Spectra