E2F-4 Transcription Factor / Biotin / 4E2F04 (WUF10)

Product Details
Supplier Thermo Fisher Scientific
Catalog #: MA511273 (View supplier product page)
Size 500 μl
Price $415.00
Antigen E2F-4 Transcription Factor
Clone 4E2F04 (WUF10)
Host Mouse
Isotype IgG1
Conjugate Biotin
Target Species Human, Rat
Applications Gel Shift, IF, WB
Description E2F-4 Transcription Factor Monoclonal Antibody, Biotin conjugate (4E2F04 (WUF10)). E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F-4 is regulated by complex formation with Rb p110. E2F family members bind DNA as heterodimers with members of the DP family of polypeptides Differential phosphorylation contributes to the microheterogeniety of E2F-4 (total aa 411-416, varies due to a trinucleotide repeat).GS 1mg/mL, IF Assay Dependent, IHC (P) 2-4 µg/ml, WB 1-2 µg/ml
About E2F-4 Transcription Factor and Biotin
E2F-4 Transcription Factor The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
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Biotin Excitation and Emission Spectra