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CD321 RealBlue 744 (H202-106, Rat) - Reactivity: Mouse
| Description |
The H202-106 monoclonal antibody specifically binds to CD321 which is also known as JAM-1 (Junctional adhesion molecule 1), Junctional adhesion molecule A (JAM-A), and F11 Receptor (F11R). CD321 is a type I transmembrane glycoprotein that includes two extracellular immunoglobulin-like domains. CD321 functions as an adhesion receptor molecule on platelets. It also supports the tight junction formation between endothelial cells, where it may regulate the transendothelial migration of leucocytes, and some epithelial cells. CD321 expression by certain subsets of tissue-derived, MHC Class II-positive thymic epithelial cells, macrophages, and dendritic cells suggest that it may play a role in the organization and function of antigen presenting cells. |
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| Conjugate | RealBlue 744 | |
| Clone | H202-106 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | BD Biosciences | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
RealBlue™ 744 from BD Biosciences is a novel multimer fluorophore for use in spectral flow cytometry applications with an optimal excitation peak at 488nm and an emission peak at 744nm. The emission peak fits neatly between the PerCP-Cy5.5/ StarBright Blue 700/ RealBlue™ 705 and the RealBlue™ 780 emission peaks which means it does not fall into a standard filter set on conventional, non-spectral flow cytometers. It exhibits minimal cross-beam excitation off the 355nm UV, 405nm violet, 561nm yellow/green and 633/647nm red lasers resulting in low potential for spillover spreading error in a multicolor flow cytometry assay.
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