FluoroFinder

	Supplier	Biotium
	Catalog #:	BNC882958-100 (View supplier product page)
	Size	100 μl
	Price	$199.00
	Antigen	Cytokeratin 15
	Clone	KRT15/2958
	Host	Mouse
	Isotype	IgG2b κ
	Conjugate	CF488A
	Target Species	Human
	Applications	FC, ICS, IHC, IHC-P, WB
	Description	Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

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Cytokeratin 15 / CF488A / KRT15/2958