Collagen VII / Unconjugated / LH7.2

Product Details
Supplier Biotium
Catalog #: BNUB2315-100 (View supplier product page)
Size 100 μl
Price $233.00
Antigen Collagen VII
Clone LH7.2
Host Mouse
Isotype IgG2a κ
Conjugate Unconjugated
Target Species Bovine, Equine, Goat, Guinea Pig, Human, Sheep
Applications FC, ICS, IF, IHC, IHC-P
Description Recognizes an epitope located on collagenase digested Type VII collagen (150 kDa), i. e. the non-helical carboxyl terminal region of the dimer. Binding is localized at the inferior border of the lamina densa as demonstrated by immunoelectron microscopy. Type VII is also found in the retina, where its function is unknown. It interacts with Laminin 5 and Fibronectin. Collagen VII is a stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
About Collagen VII and Purified
Collagen VII This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra