C-Myc / CF405S / MYC2895R

Product Details
Supplier Biotium
Catalog #: BNC042895-500 (View supplier product page)
Size 500 μl
Price $551.00
Antigen C-Myc
Clone MYC2895R
Host Rabbit
Isotype IgG
Conjugate CF405S
Target Species Human
Applications FC
Description c-Myc Oncoprotein(MYC2895R), CF405S conjugate, 0.1mg/mL
About C-Myc and CF405S
C-Myc This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
CF405S CF®405S from Biotium is a fluorophore with an excitation peak at 404 nm and an emission peak at 431 nm. It is spectrally similar to Alexa Fluor™ 405. It can be use in fluorescence microscopy, specifically its been validated in Structured Illumination (SIM), and flow cytometry. However, in flow cytometry, superior alternatives are Brilliant™ Violet 421, SuperNova v428 and StarBright Violet 440.
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CF405S Excitation and Emission Spectra