CD8a / CF568 / SK1

Product Details
Supplier Biotium
Catalog #: P009-568-125 (View supplier product page)
Size 125 μl
Price $148.00
Antigen CD8a
Clone SK1
Host Mouse
Isotype IgG1 κ
Conjugate CF568
Target Species Human
Applications FC
Description CD8a (clone SK1) is a mouse monoclonal antibody that recognizes the human protein CD8. CD8a is a common marker of cytotoxic (Killer) T cells, and is a T cell coreceptor. This CF568 antibody conjugate has been validated in flow cytometry.
About CD8a and CF568
CD8a The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
CF568 CF®568 from Biotium is a fluorophore with an excitation peak at 562 nm and an emission peak at 583 nm. It can be useful in both fluorescence microscopy and flow cytometry. It is spectrally similar to Alexa Fluor™ 568 and ATTO 565. However, in flow cytometry, a superior alternative is R-PE. In microscopy, CF®568 is validated in super-resolution imaging by STORM, STED, Structured Illumination (SIM) and TIRF.
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CF568 Excitation and Emission Spectra