CD45 / CF488A / 2D1

Product Details
Supplier Biotium
Catalog #: P012-488A-500 (View supplier product page)
Size 500 μl
Price $362.00
Antigen CD45
Clone 2D1
Host Mouse
Isotype IgG1 κ
Conjugate CF488A
Target Species Human
Applications FC
Description CD45 (clone 2D1) is a mouse monoclonal antibody that recognizes the human protein CD45. CD45 is lso known as Leukocyte Common Antigen (LCA). This CF488A antibody conjugate has been validated in flow cytometry. It is supplied at 5 uL/test, with sufficient antibody for 100 tests.
About CD45 and CF488A
CD45 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
CF488A CF®488A from Biotium is a fluorophore with an excitation peak at 490 nm and an emission peak at 515 nm. It is spectrally similar to Fluorescein, Alexa Fluor™ 488 and DyLight™ 488. It can be use in fluorescence microscopy and flow cytometry. In microscopy, CF®488A has been specifically validated for STORM, STED, Structured Illumination (SIM), 2-Photon microscopy and TIRF.
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CF488A Excitation and Emission Spectra