ErbB2 / Brilliant Blue 700 / Trastuzumab297.rMAb (also known as Trastuzumab N297A Biosimilar.rMAb)

Product Details
Supplier BD Biosciences
Catalog #: 756628 (View supplier product page)
Size 50 μg
Price $508.00
Antigen ErbB2
Clone Trastuzumab297.rMAb (also known as Trastuzumab N297A Biosimilar.rMAb)
Host Human
Isotype IgG1 κ
Conjugate Brilliant Blue 700
Target Species Human
Applications FC
Description Hu HER2 BB700 TRASMUT.RMAB 50ug
About ErbB2 and Brilliant Blue 700
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Brilliant Blue 700 Horizon Brilliant™ Blue 700 (BB700) from BD Biosciences is a tandem dye of BB515. It has an excitation peak at 484 nm and an emission peak at 695 nm, making it spectrally comparable to PerCP-Cy5.5.
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Brilliant Blue 700 Excitation and Emission Spectra