ErbB2 / RealBlue 780 / Trastuzumab297.rMAb (also known as Trastuzumab N297A Biosimilar.rMAb)

Product Details
Supplier BD Biosciences
Catalog #: 756614 (View supplier product page)
Size 50 μg
Price $376.00
Antigen ErbB2
Clone Trastuzumab297.rMAb (also known as Trastuzumab N297A Biosimilar.rMAb)
Host Human
Isotype IgG1 κ
Conjugate RealBlue 780
Target Species Human
Applications FC
Description Hu HER2 RB780 TRASMUT.RMAB 50ug
About ErbB2 and RealBlue 780
ErbB2 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
RealBlue 780 BD Horizon RealBlue™ 780 (RB780) is part of BD's new product line of laser-specific fluorochromes which are designed to minimize cross laser excitaiton. This fluorochrome has a maximum excitation wavelength of 488nm and a maximum emission wavelength of 780nm. While RB780 is excited by the 488nm blue laser, it offers miminal cross-laser excitation off of the 561nm yellow/green laser. It is designed for use in Flow Cytometry and Spectral Flow Cytometry.
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RealBlue 780 Excitation and Emission Spectra