IL-1 beta / APC / 8516
IL-1 beta / APC / 8516
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | IC201A (View supplier product page) | |
| Size | 100 Tests | |
| Price | $429.00 | |
| Antigen | IL-1 beta | |
| Clone | 8516 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | APC | |
| Target Species | Human | |
| Applications | FC, ICFC | |
| Description | Human IL-1beta/IL-1F2 APC-conjugated Antibody Intracellular Flow Cytometry = ICFC |
About IL-1 beta and APC
| IL-1 beta | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Images
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Detection of IL-1 beta/IL-1F2 in LPS-treated Peripheral Blood Mononuclear Cell Monocytes by Flow Cytometry. Peripheral blood mononuclear cell monocytes, resting (open histogram), or LPS-treated (filled histogram) were stained with Mouse Anti-Human IL-1 beta/IL-1F2 APC-conjugated Monoclonal Antibody (Catalog # IC201A) or isotype control antibody (Catalog # IC002A). View our protocol for Staining Intracellular Molecules. |
Citations
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Reviews & Ratings
APC Excitation and Emission Spectra
$429.00
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