CD40 / Brilliant Ultraviolet 615 / HB14 (also known as HB-14)

Product Details
Supplier BD Biosciences
Catalog #: 755171 (View supplier product page)
Size 50 μg
Price $524.00
Antigen CD40
Clone HB14 (also known as HB-14)
Host Mouse
Isotype IgG1 κ
Conjugate Brilliant Ultraviolet 615
Target Species Baboon, Cynomolgus macaque, Human, Rhesus macaque
Applications FC
Description Hu CD40 BUV615 HB14 50ug
About CD40 and Brilliant Ultraviolet 615
CD40 This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Brilliant Ultraviolet 615 BD Horizon Brilliant™ UltraViolet 615 (BUV615) is a tandem dye has an excitation peak at 348 nm and has an emission maximum of 616 nm. This dye is part of the Brilliant™ UltraViolet dye family, developed and sold by BD Biosciences. This family of dyes uses BUV395 as the donor so that all dyes in the family can be excited by the 355 nm UV laser. Depending on the acceptor, the dyes in this family have different relative brightness ratings.
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Brilliant Ultraviolet 615 Excitation and Emission Spectra