Frizzled-6 / DyLight 488 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-18335G (View supplier product page)
Size 100 μl
Price $499.00
Antigen Frizzled-6
Clone
Host Rabbit
Isotype IgG
Conjugate DyLight 488
Target Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF
Description Frizzled-6 Antibody [DyLight 488]
About Frizzled-6 and DyLight 488
Frizzled-6 This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra