CD40 / DyLight 550 / FGK45

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-80075R (View supplier product page)
Size 100 μl
Price $349.00
Antigen CD40
Clone FGK45
Host Rat
Isotype IgG2a
Conjugate DyLight 550
Target Species Mouse
Applications FC
Description CD40/TNFRSF5 Antibody (FGK45) [DyLight 550]
About CD40 and DyLight 550
CD40 This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
DyLight 550 DyLight™ 550 has an excitation peak at 562 nm and an emission peak at 576 nm and is spectrally similar to Alexa Fluor™ 546, Alexa Fluor™ 555, Cy3 and TRITC. DyLight™ 550 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 550 Excitation and Emission Spectra