Bim / Janelia Fluor 646 / 10B12

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-80103JF646 (View supplier product page)
Size 100 μl
Price $549.00
Antigen Bim
Clone 10B12
Host Rat
Isotype IgG2a κ
Conjugate Janelia Fluor 646
Target Species Canine, Human, Monkey, Mouse, Rat
Applications WB, FC, ELISA, IHC, ICC/IF
Description Bim Antibody (10B12) [Janelia Fluor® 646]
About Bim and Janelia Fluor 646
Bim The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra