FCRL1 / Vio Bright V423 / REA440

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-131-201 (View supplier product page)
Size 30 tests in 60 µL
Price $210.00
Antigen FCRL1
Clone REA440
Host Human
Isotype IgG1
Conjugate Vio Bright V423
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA440 recognizes the human CD307a antigen, a single-pass type I membrane protein which is also known as Fc receptor-like protein 1 (FcRL1) or immune receptor translocation-associated protein 5 (IRTA5). CD307a is preferentially expressed on naive and memory B cells. It has two ITAM-like motifs, an acidic glutamic acid residue in its transmembrane region, and three extracellular immunoglobulin-like domains. Ligands for CD307a have not been identified, but the presence of ITAM-like motifs suggests its potential for B cell–activation. | Additional information: Clone REA440 displays negligible binding to Fc receptors.
About FCRL1 and Vio Bright V423
FCRL1 This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Vio Bright V423 Vio® Bright V423 is a very bright Violet emitting synthetic fluorophore used in flow cytometry. The excitation and emission peaks are 399 nm and 420 nm, respectively, which means that this dye is optimally excited by the 405 nm Violet laser while the emission light is collected by a 450/50 bandpass filter.
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Vio Bright V423 Excitation and Emission Spectra