CD160 / Vio Bright FITC / REA669

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-131-556 (View supplier product page)
Size 30 µg in 200 µL
Price $140.00
Antigen CD160
Clone REA669
Host Human
Isotype IgG1
Conjugate Vio Bright FITC
Target Species Mouse
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Description Clone REA669 recognizes the mouse CD160 antigen, which is also known as BY55. CD160 is a 27 kDa glycoprotein which is expressed at the cell surface as a tightly disulfide-linked multimer. It binds both classical and non-classical MHC class I molecules. CD160 is a ligand for HVEM (herpes virus entry mediator), which attenuates TCR-mediated signaling. Furthermore it enhances proliferation of activated CD8+ T cells and regulates NK cell activation. | Additional information: Clone REA669 displays negligible binding to Fc receptors.
About CD160 and Vio Bright FITC
CD160 CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
Vio Bright FITC Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
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Vio Bright FITC Excitation and Emission Spectra