IL-6 / Vio 515 / REA1037

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-130-540 (View supplier product page)
Size 100 tests in 200 µL
Price $385.00
Antigen IL-6
Clone REA1037
Host Human
Isotype IgG1
Conjugate Vio 515
Target Species Human
Applications FC, Mass Cytometry
Description Clone REA1037 recognizes the Interleukin 6 (IL-6) antigen, which is originally identified as a B cell differentiation factor Il-6 is a multifunctional cytokine, which regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions. It induces the terminal maturation of activated B cells into antibody-secreting plasma cells and acts in synergy with IL-3 to support the proliferation of hematopoietic stem cells. IL-6 is produced by many cell types, such as monocytes, fibroblasts, endothelial cells, eosinophils, and T cells. Disturbed IL-6 production has been associated with pathological processes, including inflammatory autoimmune diseases and cancer. | Additional information: Clone REA1037 displays negligible binding to Fc receptors.
About IL-6 and Vio 515
IL-6 This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]
Vio 515 Vio® 515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is spectrally comparable to FITC, Alexa Fluor™ 488, CF®488A and DyLight™ 488.
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Vio 515 Excitation and Emission Spectra