CLEC4A / Vio Bright V423 / REA329

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-131-424 (View supplier product page)
Size 30 tests in 60 µL
Price $210.00
Antigen CLEC4A
Clone REA329
Host Human
Isotype IgG1
Conjugate Vio Bright V423
Target Species Human
Applications FC
Description Clone REA329 recognizes the human dendritic cell immunoreceptor (DCIR) antigen, a single-pass type II membrane protein with a single carbohydrate recognition domain which is also known as C-type lectin domain family 4 member A (CLEC4A) or lectin-like immunoreceptor (LLIR). DCIR is expressed on dendritic cells (DCs), monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. It is mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-α. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation. | Additional information: Clone REA329 displays negligible binding to Fc receptors. |
About CLEC4A and Vio Bright V423
CLEC4A This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Vio Bright V423 Vio® Bright V423 is a very bright Violet emitting synthetic fluorophore used in flow cytometry. The excitation and emission peaks are 399 nm and 420 nm, respectively, which means that this dye is optimally excited by the 405 nm Violet laser while the emission light is collected by a 450/50 bandpass filter.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Vio Bright V423 Excitation and Emission Spectra