Integrin alpha 4 beta 7 / Unconjugated / DATK32

Product Details
Supplier Leinco
Catalog #: L291-500 µg (View supplier product page)
Size 500 μg
Price $217.00
Antigen Integrin alpha 4 beta 7
Clone DATK32
Host Rat
Isotype IgG2a κ
Conjugate Unconjugated
Target Species Mouse
Applications Block, FC, IHC FF, IP
Description LPAM-1 antibody, clone DATK32, recognizes mouse lymphocyte Peyer’s patch adhesion molecule (LPAM-1), also known as integrin alpha 4 beta 7 (alpha4beta7). LPAM-1 is a heterodimer of the 154 kDa integrin alpha4 (CD49d) and 130 kDa integrin beta7 chains and is a member of the Ig superfamily. LPAM-1 is expressed on most peripheral lymphocytes, subsets of thymocytes, and bone marrow hematopoietic stem cells1,2. LPAM-1 mediates adhesion to endothelial cells, promoting leukocyte transmigration across high endothelial venules (HEVs) during the inflammatory response. LPAM-1 binds to several ligands, including vascular adhesion molecule-1 (VCAM-1/CD106), mucosal addressin cell adhesion molecule-1 (MAdCAM-1), and fibronectin. MAdCAM-1 is expressed exclusively on endothelial cells of the gut and gut-associated lymphoid tissues, such as Peyer’s patches (PPs), and binding of LPAM-1 to MAdCAM-1 contributes to lymphocyte homing to mucosal tissues3,4. Vedolizumab, an anti-LPAM-1 monoclonal antibody, is approved to treat inflammatory bowel disease and effectively induces and maintains remission in Crohn's disease and ulcerative colitis5-8.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Purified Excitation and Emission Spectra