CD25 / APC / 280406
CD25 / APC / 280406
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | FAB2438A-100 (View supplier product page) | |
| Size | 100 Tests | |
| Price | $349.00 | |
| Antigen | CD25 | |
| Clone | 280406 | |
| Host | Rat | |
| Isotype | IgG2a | |
| Conjugate | APC | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | Mouse CD25/IL-2R alpha APC-conjugated Antibody |
About CD25 and APC
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Images
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Detection of CD25/IL-2 R alpha in CD4+ Mouse T cells by Flow Cytometry. CD4+ mouse T cells treated with anti-mouse CD3 and anti-mouse CD28 for 24 hours were stained with Rat Anti-Mouse CD25/IL-2 R alpha APC-conjugated Monoclonal Antibody (Catalog # FAB2438A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins. |
Citations
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Reviews & Ratings
APC Excitation and Emission Spectra
$349.00
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