CXCL10 / APC / REA334

Product Details
Supplier Miltenyi Biotec
Catalog #: 130-128-225 (View supplier product page)
Size 100 tests in 200 µL
Price $320.00
Antigen CXCL10
Clone REA334
Host Human
Isotype IgG1
Conjugate APC
Target Species Human
Applications FC, Mass Cytometry
Description Clone REA334 recognizes the human C-X-C motif chemokine 10 (CXCL10) antigen, a secreted molecule also known as interferon gamma-induced protein (IP-10). CXCL10 is a member of the CXC chemokine family which binds to the cell surface chemokine receptor CXCR3 to exert its biological effects. It is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells, and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, anti-tumor activity, and inhibition of bone marrow colony formation and angiogenesis. It is associated with a variety of human diseases including infectious diseases, chronic inflammation, immune dysfunction, tumor development, metastasis, and dissemination. CXCL10 has been identified as a major biological marker mediating disease severity and may be utilized as a prognostic indicator for various diseases. | Additional information: Clone REA334 displays negligible binding to Fc receptors.
About CXCL10 and APC
CXCL10 This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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APC Excitation and Emission Spectra