CD22 / Vio Blue / REA340
CD22 / Vio Blue / REA340
Product Details
Supplier | Miltenyi Biotec | |
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Catalog #: | 130-130-425 (View supplier product page) | |
Size | 100 tests in 200 µL | |
Price | $395.00 | |
Antigen | CD22 | |
Clone | REA340 | |
Host | Human | |
Isotype | IgG1 | |
Conjugate | Vio Blue | |
Target Species | Human | |
Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
Description | Clone REA340 recognizes the human CD22 antigen, a single-pass type I membrane protein which is also known as sialic acid-binding Ig-like lectin 2 (Siglec-2). In peripheral blood, cell surface expression of CD22 is found on mature B cells, but is lost during terminal differentiation to plasma cells. In bone marrow, surface expression of CD22 can be detected from the pre–B cell stage on. Cytoplasmic expression of CD22 can also be found in late pro–B cells and early–B cells. CD22 plays a strong role in cell interactions and B cell activation. It is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 has emerged as an ideal target for monoclonal antibody based therapy of B cell malignancies including most lymphomas and many leukemias. | Additional information: Clone REA340 displays negligible binding to Fc receptors. |
About CD22 and Vio Blue
CD22 | Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022] | |
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Vio Blue | Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec). |
Citations
Reviews & Ratings
Vio Blue Excitation and Emission Spectra
$395.00
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