FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-127-472 (View supplier product page)
	Size	100 tests in 200 µL
	Price	$410.00
	Antigen	CD16
	Clone	REA423
	Host	Human
	Isotype	IgG1
	Conjugate	Vio Bright R720
	Target Species	Human
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC, Mass Cytometry
	Description	Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes. \| Additional information: Clone REA423 displays negligible binding to Fc receptors.

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$410.00
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CD16 / Vio Bright R720 / REA423