CD40 / PerCP-Cy5.5 / HB14
CD40 / PerCP-Cy5.5 / HB14
Citations:
(1)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 313013 (View supplier product page) | |
| Size | 25T | |
| Price | $147.00 | |
| Antigen | CD40 | |
| Clone | HB14 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | PerCP-Cy5.5 | |
| Target Species | Cynomolgus macaque, Human, Rhesus macaque | |
| Applications | FC | |
| Description | PerCP/Cyanine5.5 anti-human CD40 |
About CD40 and PerCP-Cy5.5
| CD40 | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] | |
|---|---|---|
| PerCP-Cy5.5 | PerCP-Cyanine® 5.5 (PerCP-Cy5.5) is a red-emitting tandem fluorophore that was originally designed to make the PerCP fluorophore more stable and increase signal intensity. The donor molecule, PerCP can be excited by the 488-nm blue laser and and transfers energy to the acceptor molecule, Cy5.5, which emitts light that can be captured with a 695/40 nm bandpass filter. PerCP-Cy5.5 has an excitation peak at 482 nm and an emission peak at 695 nm. There are superior alternatives to PerCP and PerCP-Cy5.5 including RealBlue 705 (BD Biosciences), NovaFluor Blue 690 or PerCP-eFluor™ 710. |
Images
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Human peripheral blood lymphocytes were stained with CD40 (clone HB14) PerCP/Cy5.5 (filled histogram) or mouse IgG1, κ PerCP/Cy5.5 isotype control (open histogram). |
Citations
| PMID 18316378 | ||
|---|---|---|
| PMID 20962324 | ||
| Additional Sources |
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Reviews & Ratings
PerCP-Cy5.5 Excitation and Emission Spectra
$147.00
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