Presenilin-1 / Alexa Fluor 647 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-76792AF647 (View supplier product page)
Size 100 μl
Price $499.00
Antigen Presenilin-1
Clone
Host Rabbit
Isotype IgG
Conjugate Alexa Fluor 647
Target Species Human, Mouse, Rat
Applications WB, ELISA, IHC, ICC/IF, IHC-P
Description Presenilin-1 Antibody [Alexa Fluor® 647]
About Presenilin-1 and Alexa Fluor 647
Presenilin-1 Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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Alexa Fluor 647 Excitation and Emission Spectra