Hsp27 / Alexa Fluor 405 / SPM252

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34751AF405 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen Hsp27
Clone SPM252
Host Mouse
Isotype IgG1 κ
Conjugate Alexa Fluor 405
Target Species Chicken, Human, Mouse, Primate, Rat, Sheep
Applications ICC/IF, WB, ELISA, FC, IHC-Fr, IHC-P, IP, IHC
Description It recognizes a 24-27kDa estrogen-regulated protein, identified as heat shock protein 27 (hsp27). Hsp27 was recently found to be identical to the estrogen-induced p29 and 24K protein. About 50% of breast carcinomas are positive for hsp27 especially those that are also positive for estrogen and/or progesterone receptor. HSP27 has also been implicated in drug resistance in cancer cells.
About Hsp27 and Alexa Fluor 405
Hsp27 This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra