MART-1 / DyLight 755 / M2-7C10 + M2-9E3

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34680IR (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen MART-1
Clone M2-7C10 + M2-9E3
Host Mouse
Isotype IgG2b κ
Conjugate DyLight 755
Target Species Human, Mouse, Rat
Applications WB, IHC-P, FC, ICC/IF, IHC-Fr, IHC
Description This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
About MART-1 and DyLight 755
MART-1 Located in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
DyLight 755 DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy.
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DyLight 755 Excitation and Emission Spectra