ABCG2 / Janelia Fluor 646 / 3G8

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-22124JF646 (View supplier product page)
Size 100 μl
Price $469.00
Antigen ABCG2
Clone 3G8
Host Mouse
Isotype IgG1
Conjugate Janelia Fluor 646
Target Species Human, Mouse, Primate
Applications WB, FC, ELISA, IHC, ICC/IF, IHC-P
Description ABCG2/CD338 Antibody (3G8) [Janelia Fluor® 646]
About ABCG2 and Janelia Fluor 646
ABCG2 The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra