PKC iota / DyLight 755 / PRKCI/4911

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-14155IR (View supplier product page)
Size 100 μl
Price $519.00
Antigen PKC iota
Clone PRKCI/4911
Host Mouse
Isotype IgG2b κ
Conjugate DyLight 755
Target Species Canine, Feline, Human
Applications IHC, IHC-P
Description PKC iota Antibody (PRKCI/4911) [DyLight 755]
About PKC iota and DyLight 755
PKC iota This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
DyLight 755 DyLight™ 755 has an excitation peak of 754 nm and an emission peak of 776 nm and is spectrally similar to Alexa Fluor™ 750. DyLight™ 755 is most commonly used in fluorescence micrscopy.
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DyLight 755 Excitation and Emission Spectra