CD28 / Alexa Fluor 405 / C28/75

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34575AF405 (View supplier product page)
Size 0.1 ml
Price $529.00
Antigen CD28
Clone C28/75
Host Mouse
Isotype IgG1 κ
Conjugate Alexa Fluor 405
Target Species Human
Applications ICC/IF, ELISA, FC, IHC-Fr, IHC-P, IHC
Description Recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
About CD28 and Alexa Fluor 405
CD28 The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra