Pax6 / Alexa Fluor 405 / PAX6/7078R

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP3-14033AF405 (View supplier product page)
Size 100 μl
Price $519.00
Antigen Pax6
Clone PAX6/7078R
Host Rabbit
Isotype IgG κ
Conjugate Alexa Fluor 405
Target Species Human
Applications WB, FC, ICC/IF
Description Pax6 Antibody (PAX6/7078R) [Alexa Fluor® 405]
About Pax6 and Alexa Fluor 405
Pax6 This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra