Bcl-10 / Alexa Fluor 405 / SPM520

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34415AF405 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen Bcl-10
Clone SPM520
Host Mouse
Isotype IgG1 κ
Conjugate Alexa Fluor 405
Target Species Human
Applications ELISA, ICC/IF, WB, FC, IHC-Fr, IHC-P, IHC
Description This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas.
About Bcl-10 and Alexa Fluor 405
Bcl-10 This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra