MSR1 / Unconjugated /

Product Details
Supplier Biorbyt
Catalog #: orb832582 (View supplier product page)
Size 10 mg
Price $3,413.60
Antigen MSR1
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species E. coli
Applications ELISA, WB
Description Rabbit polyclonal antibody to SRA.All of our unique antibodies are supplied with the following: •200 μg recombinant immunogen protein/peptide (Positive Control). •10mg Rabbit polyclonal antibody purified by Protein A/G.
About MSR1 and Purified
MSR1 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
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Purified Excitation and Emission Spectra