MSR1 / HRP / 268318

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB1797H (View supplier product page)
Size 0.1 ml
Price $529.00
Antigen MSR1
Clone 268318
Host Rat
Isotype IgG2b
Conjugate HRP
Target Species Mouse
Applications WB
Description SR-AI/MSR Antibody (268318) [HRP]
About MSR1 and HRP
MSR1 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
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HRP Excitation and Emission Spectra