p27 KIP 1 / Janelia Fluor 549 / 225501

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB2256I (View supplier product page)
Size 0.1 ml
Price $529.00
Antigen p27 KIP 1
Clone 225501
Host Mouse
Isotype IgG2b
Conjugate Janelia Fluor 549
Target Species Human, Mouse, Rat
Applications WB, ICFC
Description p27/Kip1 Antibody (225501) [Janelia Fluor® 549]
About p27 KIP 1 and Janelia Fluor 549
p27 KIP 1 This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
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Janelia Fluor 549 Excitation and Emission Spectra