LDL Receptor / APC / 263123

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB2255A (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen LDL Receptor
Clone 263123
Host Rat
Isotype IgG2a
Conjugate APC
Target Species Mouse
Applications FC
Description LDLR Antibody (263123) [Allophycocyanin]
About LDL Receptor and APC
LDL Receptor The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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APC Excitation and Emission Spectra