CD357 / Janelia Fluor 646 / 2375B

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB52412J (View supplier product page)
Size 0.1 ml
Price $509.00
Antigen CD357
Clone 2375B
Host Rabbit
Isotype IgG
Conjugate Janelia Fluor 646
Target Species Mouse
Applications FC, IHC, ICC
Description GITR/TNFRSF18 Antibody (2375B) [Janelia Fluor® 646]
About CD357 and Janelia Fluor 646
CD357 This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra