Flt-3 / DyLight 488 / 66903

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB812K (View supplier product page)
Size 0.1 ml
Price $559.00
Antigen Flt-3
Clone 66903
Host Mouse
Isotype IgG1
Conjugate DyLight 488
Target Species Human
Applications FC
Description Flt-3/Flk-2/CD135 Antibody (66903) [DyLight 488]
About Flt-3 and DyLight 488
Flt-3 This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra