ErbB4 / DyLight 488 / 182818

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB11311K (View supplier product page)
Size 0.1 ml
Price $569.00
Antigen ErbB4
Clone 182818
Host Mouse
Isotype IgG2a
Conjugate DyLight 488
Target Species Human
Applications FC
Description ErbB4/Her4 Antibody (182818) [DyLight 488]
About ErbB4 and DyLight 488
ErbB4 This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra