RANTES / DyLight 594 / 21445

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: FAB278M (View supplier product page)
Size 0.1 ml
Price $569.00
Antigen RANTES
Clone 21445
Host Mouse
Isotype IgG1
Conjugate DyLight 594
Target Species Human
Applications WB, IHC, ICFC
Description CCL5/RANTES Antibody (21445) [DyLight 594]
About RANTES and DyLight 594
RANTES This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
DyLight 594 DyLight™ 594 has an excitation peak at 593 nm and an emission peak at 618 nm and is spectrally similar to Alexa Fluor™ 594 and Texas Red. DyLight™ 594 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 594 Excitation and Emission Spectra