CD40 / APC-Fire 750 / HB14

Product Details
Supplier Sony
Catalog #: 2165110 (View supplier product page)
Size 100 Tests
Price $363.00
Antigen CD40
Clone HB14
Host Mouse
Isotype IgG1 κ
Conjugate APC-Fire 750
Target Species African Green Monkey, Baboon, Cynomolgus macaque, Human, Rhesus macaque
Applications FC
Description APC/Fire 750 anti-human CD40
About CD40 and APC-Fire 750
CD40 This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
APC-Fire 750 APC-Fire™ 750 from Biolegend has an excitation peak at 651 nm and an emission peak at 788 nm and is most commonly used in flow cytometry. Spectrally its similar to APC-Cy7, APC-Alexa 750 and APC-H7
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APC-Fire 750 Excitation and Emission Spectra