CD40 Monoclonal / Brilliant Violet 510 / 5C3
CD40 Monoclonal / Brilliant Violet 510 / 5C3
Product Details
Supplier | Sony | |
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Catalog #: | 2271645 (View supplier product page) | |
Size | 25 Tests | |
Price | $191.00 | |
Antigen | CD40 | |
Clone | 5C3 | |
Host | Mouse | |
Isotype | IgG1 κ | |
Conjugate | Brilliant Violet 510 | |
Target Species | Human | |
Applications | FC | |
Description | Brilliant Violet 510 anti-human CD40 |
About CD40 and Brilliant Violet 510
CD40 | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] | |
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Brilliant Violet 510 | Brilliant™ Violet 510 (BV510) is a green-emitting non-tandem polymer fluorophore that can be excited by the 405 nm Violet laser and collected using a 510/50 bandpass filter. BV510 has an excitation peak at 405 nm and an emission peak at 510 nm, and is similar to StarBright Violet 515 (Bio-Rad). BV510 is most often used in flow cytometry due to its improved signal-to-noise over alternatives like V500 and AmCyan. This dye is part of the Brilliant™ Violet dye line. BV510 and BV480 are the only dyes in the Brilliant™ Violet dye family that are not tandem fluorophores based off the BV421 polymer core, but they have nearly the same maximum excitation. |
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Brilliant Violet 510 Excitation and Emission Spectra
$191.00
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