FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-099-846 (View supplier product page)
	Size	30 tests in 300 µL
	Price	$145.00
	Antigen	HLA Class I Bw6
	Clone	REA143
	Host	Human
	Isotype	IgG1
	Conjugate	Vio Blue
	Target Species	Human
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC, Mass Cytometry
	Description	Clone REA143 recognizes HLA Bw6, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Downregulation of HLA class I Bw6 allele has been reported in leukemic patients where it is suggested that via this downregulation, leukemic cells may circumvent attack by CTLs. \| Additional information: Clone REA143 displays negligible binding to Fc receptors.

$145.00
Supplier Page

HLA Class I Bw6 Monoclonal / Vio Blue / REA143