FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-104-503 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$265.00
	Antigen	IL-13 R alpha 2
	Clone	REA308
	Host	Human
	Isotype	IgG1
	Conjugate	Biotin
	Target Species	Human
	Applications	FC
	Description	Clone REA308 recognizes the human CD213α2 antigen, a single-pass type I membrane protein which is also known as interleukin-13 receptor subunit α-2 (IL-13Rα2). CD213α2 is a high affinity receptor for IL-13 that is used only by IL-13 and is quite distinct from CD213α1 (IL-13Rα1) that IL-13 shares with IL-4. CD213α2 is expressed by fibroblasts, smooth muscle cells, keratinocytes, and activated B cells. It has been thought to be a decoy receptor due to its short cytoplasmic tail and it exists on the cell membrane, intracellularly, and in soluble form. Recent reports revealed that membrane CD213α2 may have some signaling capabilities, and soluble CD213α2 is a critical endogenous modulator for IL-13 responses. Additionally, IL-13 signaling via CD213α2 plays a role in tumor immune surveillance. \| Additional information: Clone REA308 displays negligible binding to Fc receptors.

	IL-13 R alpha 2	The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

$265.00
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IL-13 R alpha 2 Monoclonal / Biotin / REA308