FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-104-560 (View supplier product page)
	Size	30 tests in 300 µL
	Price	$160.00
	Antigen	CD46
	Clone	REA312
	Host	Human
	Isotype	IgG1
	Conjugate	APC-Vio770
	Target Species	Human
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA312 recognizes the human CD46 antigen, a type I transmembrane glycoprotein, which is also known as the membrane cofactor protein (MCP). At least fourteen different transcript variants encoding different isoforms have been found for CD46. It is expressed by a broad range of tissues including leukocytes, platelets, epithelial cells, and fibroblasts, but not by erythrocytes. CD46 acts as a co-factor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It is involved in the fusion of the spermatozoa with the oocyte during fertilization. Additionally, CD46 functions as a receptor for measles virus, human herpesvirus, and human adenovirus. It is a potent costimulator for the induction of interferon-γ secreting effector T helper type 1 cells and their subsequent switch into interleukin 10 producing regulatory T cells. \| Additional information: Clone REA312 displays negligible binding to Fc receptors. \|

	CD46	The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
	APC-Vio770	APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

$160.00
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CD46 Monoclonal / APC-Vio770 / REA312