FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-105-547 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$300.00
	Antigen	BTK
	Clone	REA367
	Host	Cell Line
	Isotype	IgG1
	Conjugate	APC
	Target Species	Human
	Applications	FC
	Description	Clone REA367 recognizes the human bruton tyrosine kinase (Btk) antigen, a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B cell–development, –differentiation, and –signaling. Moreover, Btk expression is assumed to be a prerequisite for B cell–proliferation and –survival. Consequently, Btk-deficient B lymphocytes fail to reach the mature state and are presumably doomed to premature death. Btk is reported to be associated with human disease. Thus, individuals harboring loss-of-function mutations in the gene encoding Btk virtually lack circulating B lymphocytes, are unable to generate immunoglobulins of all classes, and therefore cannot mount humoral immune responses. This primary immunodeficiency is named X-linked agammaglobulinemia. \| Additional information: Clone REA367 displays negligible binding to Fc receptors.

	BTK	The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$300.00
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BTK Monoclonal / APC / REA367